NMR Mapping and Modeling of Intrinsically Disordered Proteins
Utilize nuclear magnetic resonance (NMR) techniques to capture the dynamic ensembles of intrinsically disordered proteins, enabling accurate modeling of their fluctuating structures.
Current structure prediction tools like AlphaFold excel for stable proteins but struggle with highly dynamic proteins whose structures fluctuate continuously, leaving a gap in our understanding of intrinsically disordered proteins and protein allostery.