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Biophysics
Index: #20

Difficulty Delivering Physical Probes for Imaging into Living Cells

Delivering physical probes for imaging into living cells is challenging due to barriers in cell membranes and potential perturbation of cellular function. New approaches are required to enable high-dimensional biosensing without invasive probes.

Foundational Capabilities (2)

Label-Free High-Dimensional Biosensing

Develop label-free biosensing techniques that leverage vibrational signatures to capture complex cellular information without the need for physical probe delivery.
  • Prediction of single-cell RNA expression profiles in live cells by Raman microscopy with Raman2RNA
    Research and Reviews

    • Metabolically Incorporated Labels

    Engineer cells to incorporate imaging labels metabolically, thereby eliminating the need for external probe delivery and enabling noninvasive imaging.
  • Super-multiplex vibrational imaging
    Technology Seed