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Biophysics
Index: #19

Light Scattering in Living Tissue Prevents Optical Access to Deeper Regions

Living tissue exhibits strong light scattering, which hampers deep-tissue imaging and limits resolution. Overcoming this barrier is critical for mapping neural activity and enabling noninvasive diagnostic imaging.

Foundational Capabilities (2)

Anti-Scattering Optical and Opto-Acoustic Methods

Develop novel optical and opto-acoustic techniques that reduce scattering, enabling deep-tissue imaging without expensive MRI. These methods aim to improve resolution and enable whole-brain activity mapping as well as cost-effective “body scanners” for diagnostics.
  • Openwater
    Company
  • An integrated photonic engine for programmable atomic control
    Research and Reviews
  • Nonlinear sound-sheet microscopy: Imaging opaque organs at the capillary and cellular scale
    Research and Reviews
  • Resonant Spatial Light Modulation: Optical Programming and Sensing at the Fundamental Limit
    Research and Reviews
  • Single-impulse Panoramic Photoacoustic Computed Tomography of Small-animal Whole-body Dynamics at High Spatiotemporal Resolution
    Research and Reviews
  • Imaging, Sensing, and Communication Through Highly Scattering Complex Media
    Roadmap
  • Deep Tissue Imaging (Phase 2)
    Whitepapers and Essays

    • Magnetic-Based Imaging

    Develop magnetic imaging (magneto-genetics) approaches as an alternative modality that circumvents the limitations of optical scattering, potentially offering noninvasive imaging of deep tissue structures.
  • Mechanism of giant magnetic field effect in fluorescence of mScarlet3, a red fluorescent protein
    Research and Reviews
  • Magnetic control of the brightness of fluorescent proteins
    Technology Seed