Under-Provisioning of Antibiotics, Vaccines and Other Interventions for Major Global Health Challenges
Many of the world’s most deadly diseases—such as tuberculosis, Group A Streptococcus, hepatitis C, hepatitis B, and syphilis—lack effective vaccines or cures. Additionally, the pace of developing effective, low-cost, therapeutics for emerging pathogens in low resource settings is too slow to meet global health needs. Malnutrition exacerbates susceptibility to disease and impedes recovery; food security is important especially for early child development. Understanding the basic science of malnutrition during development is important for the development of more effective interventions.
Foundational Capabilities (3)
Accelerate clinical trials and support research into novel vaccine technologies that can be distributed in low-resource settings, especially those that do not require cold chain.
New treatments for chronic infections (e.g., achieving a functional cure for hepatitis B) and novel monoclonal antibodies for diseases such as malaria.
New formulations (e.g., one time dose time release delivery) could improve delivery and compliance in low resource settings.