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Physiology and Medicine

Delivery Systems that “De-Target” the Liver and Macrophages

New delivery mechanisms are needed to target the desired tissues and avoid uptake by hepatocytes and macrophages. Off-target uptake necessitates higher dosing, increasing toxicity risks.

Resources (4)

Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy
Technology Seed
Drug delivery with living cells
Technology Seed
Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors
Technology Seed
The evolution of commercial drug delivery technologies
Technology Seed

R&D Gaps (1)

We Can’t Safely and Controllably Deliver Complex Molecular Payloads to the Targets We Want in the Body

Physiology and Medicine
Current in-vivo delivery systems (viral vectors, nanoparticles, microchips) face challenges such as off-target accumulation and inefficiency, particularly in delivering therapies to the brain. Novel delivery approaches are needed to improve targeting and performance.
Physiology and Medicine
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