Physiology and Medicine
Our ability to advance medicine is limited by the rate at which we can conduct human experiments and the translatability of our experimental models. Improving medicine by expanding our understanding of and ability to modulate living humans. Aging research requires that we understand what’s happening in humans over long timescales, and that we can identify biomarkers that can proxy these trends.
R&D Gaps (6)
Current preclinical models of human physiology, including animals and organoids, do not fully capture the complexity of human physiology, limiting the predicting power of preclinical experiments and explaining, in part, the costly failures of drug development in clinical trials. This is especially t...
Our understanding of human physiology and disease remains incomplete. In the last century, we have developed cures for many diseases with well-defined root causes (polio, smallbox, cholera, SMA, cervical cancer, etc.). However, a wide array of conditions still eludes cures and treatments. We have ye...
Drug development is often hampered by failures related to absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox). Improved predictive models for molecular interactions are essential for designing safer, more effective drugs, as well as evaluating the impact of environmental chemica...