Grow and Maintain Human Organs Ex Vivo or in Animals
Grow human organs in animals to study disease and drug response more accurately. Use advanced stem cell technologies to grow patient-specific tissues and organs in animals for transplantation.
Human organs could also be maintained ex vivo (“in a vat”) for research purposes. Perfused organ systems (including cadaver-based models) that maintain the structure and function of human tissues ex vivo would also be enabling.
Resources (4)
Excluding Oct4 from Yamanaka Cocktail Unleashes the Developmental Potential of iPSCs
Research and Reviews
Gene-edited pig kidney transplanted into a living patient for the first time
Research and Reviews
Bexorg
Company
Pluripotency Superstar Oct4 Gets a Makeover
Whitepapers and Essays
R&D Gaps (1)
Current preclinical models of human physiology, including animals and organoids, do not fully capture the complexity of human physiology, limiting the predicting power of preclinical experiments and explaining, in part, the costly failures of drug development in clinical trials. This is especially t...