High-Throughput Single-Cell Proteomics
Develop new technologies to improve the cost-performance of single-cell
proteomics (>100x), enabling proteome-wide analysis at scale. This would
allow proteins—the functional output of genetics—to be analyzed
comprehensively across complex biological systems. Some of these technologies
are single-molecule, some are not.
Resources (4)
Quantum SI
Company
Sampling the proteome by emerging single-molecule and mass spectrometry methods
Whitepapers and Essays
R&D Gaps (1)
Many of the fundamental actors in cells—proteins, lipids, and metabolites—are still mostly invisible to us, especially when considering their extensive multiplexity, diversity, cell-to-cell heterogeneity, and temporal variation. Without scalable, cost-effective technologies to capture these molecula...