Cellular and Molecular Biology
Cells, organs, organisms and notably brains could be observable and perturbable with far greater spatiotemporal precision, multiplexing of targets/variables and 3D access through better physical and chemical tools.
R&D Gaps (3)
Many of the fundamental actors in cells—proteins, lipids, and metabolites—are still mostly invisible to us, especially when considering their extensive multiplexity, diversity, cell-to-cell heterogeneity, and temporal variation. Without scalable, cost-effective technologies to capture these molecula...
We are currently limited in our ability to image molecules in their native contexts—for example, within live 3D tissues. Achieving scalable, high-resolution imaging of biomolecules in situ would de-risk many areas of biomedical science by enabling integrative, comprehensive molecular mapping within ...