Immune Tolerance Induction to Enable In-Human Synthetic Biology with Foreign Proteins

We need a way to programmably induce immune tolerance to a user-defined foreign protein, in order to enable many new forms of gene and cell therapy (not to mention help with autoimmune diseases). This is especially needed for brain computer interface as many of the most powerful concepts for BCI would involve adding foreign protein such as transducer proteins for optical or acoustic signals. As Hannu Rajaniemi wrote, “a flexible ability to induce immune tolerance to opsins is a prerequisite of a two-way mind meld with computers”.