Immunology

In principle, the immune system surveys essentially the entire body and stores a memory of much of what it finds. The system is theoretically highly programmable by inserting or removing DNA-encoded adaptive immune receptor molecules. However, our current ability to read-write this system is limited and new tools and datasets are needed to harness its power. While data suggest that antigens displayed on the cell surface may not be well predicted by DNA sequences and genetic code, the ability to unbiasedly identify and de novo sequence antigens remains limited.