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Low Energy Multiphoton Brain Imaging

Develop a novel physical pathway for multiphoton fluorescence generation that enables optical sectioning and excitation at red wavelengths with simple systems like continuous wave lasers.

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Capturing the dynamics of large brain networks at single-neuron resolution in vivo is extremely challenging. Advanced imaging methods that record fast, high-resolution activity without destructive intervention are required to unravel the complex interplay of neuronal circuits in real time.