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Neuroscience
Index: #4

We Can’t Take High-Resolution Movies of or Intervene in Brain Computation at the Single Neuron Level

Capturing the dynamics of large brain networks at single-neuron resolution in vivo is extremely challenging. Advanced imaging methods that record fast, high-resolution activity without destructive intervention are required to unravel the complex interplay of neuronal circuits in real time.

Foundational Capabilities (4)

In-Vivo Connectomics

Create methods to map neuronal connectivity in living brains, capturing the dynamic interactions between neurons at a single-cell level.
  • Cortico-cortical feedback engages active dendrites in visual cortex
    Technology Seed

    • In-Vivo Optical Transparency of Brain Tissue

    Develop techniques that render brain tissue optically transparent in vivo, allowing deeper and higher-resolution imaging of neural networks without invasive sectioning.
  • In Vivo Optical Clearing of Mammalian Brain
    Technology Seed

    • Low Energy Multiphoton Brain Imaging

    Develop a novel physical pathway for multiphoton fluorescence generation that enables optical sectioning and excitation at red wavelengths with simple systems like continuous wave lasers.
  • Triplet Imaging
    Company

    • Novel Fast-Scanning Microscopy of Brain Cortex

    Develop innovative microscopy techniques that enable rapid, high-resolution imaging of neuronal networks in vivo at single–neuron resolution (e.g., Light Beads Microscopy)
  • High-speed, cortex-wide volumetric recording of neuroactivity at cellular resolution using light beads microscopy
    Technology Seed