Mapping Other Key Biomolecules
Develop technology suites for single-cell glycomics and lipidomics using
methods such as in-situ multi-cycle imaging or spatially resolved
nanopore/mass spectrometry. This would scale up the mapping of key molecules
beyond proteins and metabolites.
Resources (4)
Advancing Solutions to the Carbohydrate Sequencing Challenge
Research and Reviews
Gel-assisted mass spectrometry imaging enables sub-micrometer spatial lipidomics
Research and Reviews
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease
Research and Reviews
R&D Gaps (1)
Many of the fundamental actors in cells—proteins, lipids, and metabolites—are still mostly invisible to us, especially when considering their extensive multiplexity, diversity, cell-to-cell heterogeneity, and temporal variation. Without scalable, cost-effective technologies to capture these molecula...