Biosecurity

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Biosecurity confronts the dynamic challenge of rapidly evolving microbes and the potential for malicious misuse of biotechnology. As pathogens and bad actors continuously adapt, it is critical to develop innovative approaches—from next-generation antibiotics and vaccines to advanced early-warning systems—to safeguard public health and critical infrastructure. Biosecurity is currently receiving very few resources relative to the level of unmet need, particularly with the proliferation of AI capabilities that could increase the number of capable bad actors.

R&D Gaps (5)

Pathogenic microbes evolve quickly, and bad actors may exploit biotechnology for harmful purposes. Our current defenses struggle to keep pace with these evolving threats.

Our ability to block the transmission of pathogens is limited. Without effective strategies, airborne and surface-based transmission continues to spread diseases. A meta roadmap is here.

Rapid detection of emerging bio-threats is critical for effective intervention and containment. However, many pathogens are detected only after widespread transmission has occurred. In addition, attributing the source of these threats remains challenging.

Advances in synthetic biology have unlocked unprecedented innovations, but also raise concerns about the potential for harmful bioengineering. Preventing misuse requires robust screening and control measures around DNA synthesis. Implementation must be coordinated and universal to effectively minimi...

Many critical supply chains and infrastructure systems are fragile and lack robust backup mechanisms, leaving society vulnerable.

R&D Gaps (5)

Microbes Quickly Out-Evolve Our Defenses

Inadequate Blockers of Transmission

Insufficient Surveillance of Bio-Threats

Risks of Malicious Bioengineering

Fragile Supply Chains and Lack of Backup for Critical Infrastructure