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Immunology
Index: #6

Our Immune System Can Uniquely Recognize Nearly Any Molecule but We Don’t Know the Recognition Code

A better understanding of how the immune system interacts at the molecular level with threats and triggers is critical. This knowledge would enable the development of predictive tools and technologies to augment immune responses—improving interventions against infections, cancers, and autoimmune disorders.

Foundational Capabilities (1)

T-cell and B-cell Receptor Antigen Mapping

Construct a comprehensive map linking trillions of T-cell receptors (TCRs) and B-cell receptors (BCRs) to millions of disease antigens. This map will facilitate antibody–antigen binding prediction, allowing the identification of target antigens based solely on immune cell DNA sequences.
  • Adaptive Biotechnologies
    Company
  • Challenge: Decipher the T-cell receptor cancer-recognition code.
    Initiative
  • A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding
    Research and Reviews
  • TRAIT: A Comprehensive Database for T-cell Receptor-Antigen Interactions
    Research and Reviews