Protein Design Has Been Limited to Static, Bio-mimetic Structures
Protein engineering has largely focused on designing static structures that closely mimic natural proteins. This narrow approach limits the creation of truly novel or highly functional enzymes.
Foundational Capabilities (5)
Expand the operating range of biological enzymes to new solvents, enabling anhydrous enzymes, gas phase and vacuum biochemistry
Leverage generative AI to design new enzymes with novel functions by predicting active conformations and optimizing catalytic activity. Especially for complex redox reactions and reactions that go beyond classic biological catalysis.
Expand the chemical diversity of proteins by incorporating non-canonical amino acids, thereby enabling functions beyond those accessible with natural amino acids.
Develop techniques for “protein carpentry” that allow for the precise construction and remodeling of protein structures to yield dynamic, functional enzymes.