Molecular 3D Scanning
Create whole-cell, nanometer-resolved, in-situ multi-omic imaging
approaches that can map hundreds to thousands of molecules (e.g., proteins,
RNAs) within intact specimens at nanoscale resolution. The core chemistries
and imaging technologies for this exist, but they need to be integrated and
brought to scale. We could, for example, comprehensively measure the many
aspects of the “Hallmarks of Aging” within a single tissue sample.
Resources (2)
CryoET Data Portal
Technology Seed
Optimized Nanoscale Expansion microscopy
Technology Seed
R&D Gaps (1)
We are currently limited in our ability to image molecules in their native contexts—for example, within live 3D tissues. Achieving scalable, high-resolution imaging of biomolecules in situ would de-risk many areas of biomedical science by enabling integrative, comprehensive molecular mapping within ...